Article

EZH2 inhibitors-mediated epigenetic reactivation of FOSB inhibits triple-negative breast cancer progress

2020-05-18

Abstract excerpt

<title>Abstract</title> <p><bold>BACKGROUND: </bold>Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer that lacks expression of estrogen receptor (ER) and progesterone receptor (PR) and the human epidermal growth factor receptor 2 (HER2) gene. Chemotherapy remains the standard of care for TNBC treatment, but considerable patients are very resistant to chemotherapy. Mutations or a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a5c7070-cad4-5d0e-9d4d-cd673ab40618
DOI: 10.21203/rs.3.rs-16904/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

EZH2 inhibitors-mediated epigenetic reactivation of FOSB inhibits triple-negative breast cancer progressDOI 10.21203/rs.3.rs-16904/v2Read

EZH2 inhibitors-mediated epigenetic reactivation of FOSB inhibits triple-negative breast cancer progressSemantic proximity Read

Epigenetics of Triple-Negative Breast Cancer via Natural CompoundsSemantic proximity Read

Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.Semantic proximity Read

Characterizing novel molecular mechanisms involved in breast cancer tumourigenesis/progression and tamoxifen resistanceSemantic proximity Read

CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1Semantic proximity Read

FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer CarcinogenesisSemantic proximity Read

Targeting FOS attenuates malignant phenotypes of breast cancer: Evidence from in silico and in vitro studies.Semantic proximity Read

NF-κB Epigenetic Attractor Landscape Drives Breast Cancer HeterogeneitySemantic proximity Read

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast CancerSemantic proximity Read

Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast CancerSemantic proximity Read

The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer.Semantic proximity Read

<i>FOXK2</i> amplification and overexpression promotes breast cancer development and chemoresistanceSemantic proximity Read