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Article

CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1

30 Aug 2021

Abstract excerpt

Failures to treat triple-negative breast cancer (TNBC) are mainly due to chemoresistance or radioresistance. We and others previously discovered that zinc finger E-box-binding homeobox 1 (ZEB1) is a massive driver causing these resistance. However, how to dynamically modulate the intrinsic expression of ZEB1 during cell cycle progression is elusive. Here integrated affinity purification combined with mass...

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PMID: 34462429
DOI: 10.1038/s41419-021-04114-8

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