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Article

The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer.

Cancer research - 1 Mar 2019

El Ayachi Ikbale, Fatima Iram, Wend Peter, Alva-Ornelas Jackelyn A, Runke Stephanie, Kuenzinger William L, Silva Julio, Silva Wendy, Gray Joseph K, Lehr Stephan, Barch Hilaire C, Krutilina Raisa I, White Andrew C, Cardiff Robert, Yee Lisa D, Yang Lily, O'Regan Ruth M, Lowry William E, Seagroves Tiffany N, Seewaldt Victoria, Krum Susan A, Miranda-Carboni Gustavo A

Abstract excerpt

Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 proteins is observed in MMTV-Wnt10bLacZ transgenic mice during metastasis, and Hmga2...

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Source

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Identifiers

PMID: 30563890
DOI: 10.1158/0008-5472.CAN-18-1069
PMCID: PMC6855600

Genes

HMGA2
WNT10B
AXIN2
MYC
TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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