Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments

18 Jan 2017

Abstract excerpt

Musculoskeletal diseases have been associated with inflammatory cytokine action, particularly action by TNF-α and IL-1β. These inflammatory cytokines promote apoptosis and senescence of cells in diseased tissue and extracellular matrix breakdown. Stem cell-based therapies are being considered for the treatment of musculoskeletal diseases, but the presence of these inflammatory cytokines will have similar...

Topics

Join the communities discussing this publication.

CAR-T cell therapy research
Immune Cell Function and Interaction
RNA Interference and Gene Delivery

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28095751
DOI: 10.1089/ten.tea.2016.0441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory EnvironmentsPMID 28095751Read ↗

Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc DegenerationSemantic proximity Read ↗

CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation‐Resistant TissuesSemantic proximity Read ↗

Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic DrugsSemantic proximity Read ↗

Two reactive behaviors of chondrocytes in an IL-1β-induced inflammatory environment revealed by the single-cell RNA sequencingSemantic proximity Read ↗

CRISPR interference-mediated silencing of pro-inflammatory genes in autoimmune models: functional and biophysical evaluation with sustained effects in primary human PBMCsSemantic proximity Read ↗

A Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug DeliverySemantic proximity Read ↗

Tumor necrosis factor receptor 1 is required for human umbilical cord-derived mesenchymal stem cell-mediated rheumatoid arthritis therapySemantic proximity Read ↗

CRISPR/cas9 mediated knockout of an intergenic variant rs6927172 identified IL-20RA as a new risk gene for multiple autoimmune diseases.Semantic proximity Read ↗

Streamlined, single-step non-viral CRISPR-Cas9 knockout strategy enhances gene editing efficiency in primary human chondrocyte populationsSemantic proximity Read ↗

Effect of Inflammatory Microenvironment on the Regenerative Capacity of Adipose-Derived Mesenchymal Stem CellsSemantic proximity Read ↗

Immunotherapy with Pro-regenerative Macrophages from Embryonic Stem Cells Ameliorate Osteoarthritis via TNFAIP3-Mediated ChondroprotectionSemantic proximity Read ↗

A genome-wide CRISPR screen supported by human genetics identifies the <i>TNRC18</i> gene locus as a novel regulator of inflammatory signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.