Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation‐Resistant Tissues

10 Nov 2016

Abstract excerpt

OBJECTIVE: Proinflammatory cytokines such as interleukin-1 (IL-1) are found in elevated levels in diseased or injured tissues and promote rapid tissue degradation while preventing stem cell differentiation. This study was undertaken to engineer inflammation-resistant murine induced pluripotent stem cells (iPSCs) through deletion of the IL-1 signaling pathway and to demonstrate the utility of these cells for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Mesenchymal stem cell research
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27813286
DOI: 10.1002/art.39982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation‐Resistant TissuesPMID 27813286Read ↗

CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory EnvironmentsSemantic proximity Read ↗

Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic DrugsSemantic proximity Read ↗

Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc DegenerationSemantic proximity Read ↗

A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered TissuesSemantic proximity Read ↗

Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary ImmunodeficienciesSemantic proximity Read ↗

Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived MacrophagesSemantic proximity Read ↗

A Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug DeliverySemantic proximity Read ↗

Inflammasome Modulation Enhances the Immunoregulatory Function of Mesenchymal Stromal Cells under Bacterial and Titanium-induced InflammationSemantic proximity Read ↗

Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug DeliverySemantic proximity Read ↗

CRISPR-Cas9 Editing of TLR4 to Improve the Outcome of Cardiac Cell TherapySemantic proximity Read ↗

A genome-wide CRISPR screen supported by human genetics identifies the <i>TNRC18</i> gene locus as a novel regulator of inflammatory signalingSemantic proximity Read ↗

Modulating Inflammation in Post-Traumatic Osteoarthritis using iPSC-derived Anti-inflammatory MacrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.