Article

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription

2024-11-20

Abstract excerpt

Independently of the pathways or circuits deregulated in cancer cells, these present altered transcription patterns, often also direct consequence of deregulation of transcription factors. In this sense, also the RNA Polymerase complexes responsible for transcription can be affected in cancers. We find that upregulations of RNA Polymerase II subunits, especially the largest ones, correlates with poor cancer patien...

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Literature Corpus work: 12e5dd00-cd56-5fce-8dc3-4d7fc6514b1f
DOI: 10.1101/2024.11.20.622938

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