Article

Characterization of the Human TARDBP Gene Promoter

2020-11-25

Abstract excerpt

The expression of TDP-43, the main component of neuronal intracellular inclusions across a broad spectrum of ALS and FTD disorders, is developmentally regulated and studies in vivo have shown that TDP-43 overexpression can be toxic, even before observation of pathological aggregates. Starting from these observations, the regulation of its expression at transcriptional level might represent a further key element fo...

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Literature Corpus work: 2a091d7e-c6ae-5ed8-8716-ba7f42ca982d
DOI: 10.21203/rs.3.rs-110373/v1

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