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Article

UG repeats/TDP-43 interactions near 5' splice sites exert unpredictable effects on splicing modulation.

Journal of molecular biology - 6 Jan 2012

Passoni Monica, De Conti Laura, Baralle Marco, Buratti Emanuele

Abstract excerpt

TDP-43 is a nuclear protein implicated in the pathogenesis of several neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration, with broad involvement in numerous stages of RNA processing ranging from transcription to translation. In diseased neurons, TDP-43 mostly aggregates in the cytoplasm, suggesting that a loss of protein function in the nucleus may play an...

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Identifiers

PMID: 22100394
DOI: 10.1016/j.jmb.2011.11.003

Genes

BRCA1
ETF1
RXRG

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