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Article

Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis.

RNA (New York, N.Y.) - 1 Aug 2015

D'Alton Simon, Altshuler Marcelle, Lewis Jada

Abstract excerpt

TDP-43 is a soluble, nuclear protein that undergoes cytoplasmic redistribution and aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 autoregulates the abundance of its own transcript TARDBP by binding to an intron in the 3' untranslated region, although the mechanisms underlying this activity have been debated. Herein, we provide the most extensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26089325
DOI: 10.1261/rna.047647.114
PMCID: PMC4509932

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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