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Article

Increased cytoplasmic<i>TARDBP</i>mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

2 Jun 2016

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder. In motor neurons of ALS, TAR DNA binding protein-43 (TDP-43), a nuclear protein encoded by TARDBP, is absent from the nucleus and forms cytoplasmic inclusions. TDP-43 auto-regulates the amount by regulating the TARDBP mRNA, which has three polyadenylation signals (PASs) and three additional alternative introns within the last exon. However, it...

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PMID: 27257061
DOI: 10.1093/nar/gkw499

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