Article
Isolation and functional characterisation of the promoter region of the human prion protein gene.
Gene - 2 May 2001
Mahal S P, Asante E A, Antoniou M, Collinge J
Abstract excerpt
The human prion protein gene (PRNP) encodes a 33-35 kDa cell surface protein that is highly expressed in the central nervous system and is vital to the pathogenesis of prion diseases. We have characterised the promoter region of PRNP as a first step towards defining the mechanisms regulating its expression. Sequence analysis of a 2.7 kb genomic DNA fragment containing exon I and the 5'-flanking region of PRNP,...
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