Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TDP-43 Overexpression Enhances Exon 7 Inclusion during the Survival of Motor Neuron Pre-mRNA Splicing

15 Aug 2008

Abstract excerpt

TDP-43 is a highly conserved, 43-kDa RNA-binding protein implicated to play a role in transcription repression, nuclear organization, and alternative splicing. More recently, this factor has been identified as the major disease protein of several neurodegenerative diseases, including frontotemporal lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. For the splicing activity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18703504
DOI: 10.1074/jbc.m805376200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TDP-43 Overexpression Enhances Exon 7 Inclusion during the Survival of Motor Neuron Pre-mRNA SplicingPMID 18703504Read ↗

TDP-43: a DNA and RNA binding protein with roles in neurodegenerative diseases.Semantic proximity Read ↗

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Semantic proximity Read ↗

The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.Semantic proximity Read ↗

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.Semantic proximity Read ↗

TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.Semantic proximity Read ↗

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Semantic proximity Read ↗

Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathiesSemantic proximity Read ↗

Connecting TDP-43 Pathology with Neuropathy.Semantic proximity Read ↗

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes.Semantic proximity Read ↗

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulationSemantic proximity Read ↗

TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA.Semantic proximity Read ↗

Nuclear factor TDP‐43 can affect selected microRNA levelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.