Article

Expression of MMP-11, an estrogen-suppressed gene in MCF-7 cells, is elevated upon acquisition of tamoxifen resistance

2025-02-17

Abstract excerpt

Matrix metalloproteinase-11 (MMP-11), also known as stromelysin-3, is a member of a large family of zinc-dependent proteinases. Known to be expressed in breast tumor stroma, the epithelium, and the associated mononuclear inflammatory cells, its expression is associated with invasion, metastasis, and poor clinical outcomes and survival rates. Despite the known effects of estrogen on extracellular matrix remodeling,...

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Literature Corpus work: 2a08b7aa-6c72-5b50-8010-25ebe7ea12ba
DOI: 10.1101/2025.02.13.638037

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