Article

Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

2022-11-22

Abstract excerpt

<h4>ABSTRACT</h4> A key feature of advanced brain aging includes structural defects of intracortical myelin that are associated with secondary neuroinflammation. A similar pathology is seen in specific myelin mutant mice that model ‘advanced brain aging’ and exhibit a range of behavioral abnormalities. However, the cognitive assessment of these mutants is problematic because myelin-dependent motor-sensory functio...

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Literature Corpus work: 29ddc118-64cc-51eb-b045-e70810daf6ba
DOI: 10.1101/2022.11.21.517320

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