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A myelin gene causative of a catatonia‐depression syndrome upon aging

4 Apr 2012

Abstract excerpt

Severe mental illnesses have been linked to white matter abnormalities, documented by postmortem studies. However, cause and effect have remained difficult to distinguish. CNP (2',3'-cyclic nucleotide 3'-phosphodiesterase) is among the oligodendrocyte/myelin-associated genes most robustly reduced on mRNA and protein level in brains of schizophrenic, bipolar or major depressive patients. This suggests that CNP...

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PMID: 22473874
DOI: 10.1002/emmm.201200230

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