Article
Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Apr 2008
Hulshagen Leen, Krysko Olga, Bottelbergs Astrid, Huyghe Steven, Klein Rüdiger, Van Veldhoven Paul P, De Deyn Peter P, D'Hooge Rudi, Hartmann Dieter, Baes Myriam
Abstract excerpt
Peroxisomal metabolism is essential for normal brain development both in men and in mice. Using conditional knock-out mice, we recently showed that peroxisome deficiency in liver has a severe and persistent impact on the formation of cortex and cerebellum, whereas absence of functional peroxisomes from the CNS only causes developmental delays without obvious alteration of brain architecture. We now report that a...
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