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Article

Microglia ablation alleviates myelin-associated catatonic signs in mice.

The Journal of clinical investigation - 1 Feb 2018

Janova Hana, Arinrad Sahab, Balmuth Evan, Mitjans Marina, Hertel Johannes, Habes Mohamad, Bittner Robert A, Pan Hong, Goebbels Sandra, Begemann Martin, Gerwig Ulrike C, Langner Sönke, Werner Hauke B, Kittel-Schneider Sarah, Homuth Georg, Davatzikos Christos, Völzke Henry, West Brian L, Reif Andreas, Grabe Hans Jörgen, Boretius Susann, Ehrenreich Hannelore, Nave Klaus-Armin

Abstract excerpt

The underlying cellular mechanisms of catatonia, an executive "psychomotor" syndrome that is observed across neuropsychiatric diseases, have remained obscure. In humans and mice, reduced expression of the structural myelin protein CNP is associated with catatonic signs in an age-dependent manner, pointing to the involvement of myelin-producing oligodendrocytes. Here, we showed that the underlying cause of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29252214
DOI: 10.1172/JCI97032
PMCID: PMC5785265

Genes

CNP
CSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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