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Germline Nuclear-predominant Pten Murine Model Exhibits Impaired Social and Perseverative Behavior, Microglial Activation, and Increased Oxytocinergic Activity

2020-10-30

Abstract excerpt

<title>Abstract</title> <p>BackgroundAutism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene <italic>PTEN</italic> is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific <italic>Pten </italic>loss or mutation has provided insight into how disruptions to the function of PTEN affect neurodevelopment, neurobiology, and social b...

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Literature Corpus work
00b52ba4-0115-54ab-8782-c56aaac3a129
DOI
10.21203/rs.3.rs-97746/v1
Open publication

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Germline Nuclear-predominant Pten Murine Model Exhibits Impaired Social and Perseverative Behavior, Microglial Activation, and Increased Oxytocinergic ActivityDOI 10.21203/rs.3.rs-97746/v1
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