Article

A Multiscale Signaling–Biophysical Framework Reveals Mechanisms of Macrophage-Mediated RBC Clearance in Sickle Cell and Gaucher Disease

2026-04-22

Abstract excerpt

Red blood cell (RBC) clearance by macrophages maintains blood homeostasis and is dysregulated in the hemolytic disorder sickle cell disease (SCD) and the lysosomal storage disorder Gaucher disease (GD), where biophysical and biochemical alterations promote premature phagocytosis. We develop a multiscale hybrid modeling framework integrating signaling dynamics, biophysical simulations, and machine learning to inves...

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Literature Corpus work: 29b21124-ab5a-59f8-8886-c503929636f8
DOI: 10.64898/2026.04.20.719505

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