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Erythrocytic vacuoles that accumulate a fluorescent dye predict spleen size and function in sickle cell disease

19 Aug 2022

Abstract excerpt

The human spleen protects against blood-borne infections and filters red blood cells (RBC). Defective spleen function (hyposplenism) is mostly caused by splenectomy or by immunological or hematological diseases.1 Hyposplenism occurs during infancy in sickle cell disease (SCD) and shows no clear correlation with spleen size.2 Spleen function is assessed by scintigraphy, and by quantifying circulating blood cells,...

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PMID: 36056794
DOI: 10.1002/ajh.26690

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