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Article

Multi-scale immune selection and the transmission-diversity feedback of <i>Plasmodium falciparum</i> malaria

2017-07-14

Abstract excerpt

Antigenic diversity is a key factor underlying the complex epidemiology of Plasmodium falciparum malaria. Within-host clonal antigenic variation limits host exposure to the parasite’s antigenic repertoire, while the high degree of diversity at the population-level requires multiple exposures for hosts to acquire anti-disease immunity. This diversity is predominantly generated through mitotic and meiotic recombina...

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Literature Corpus work
29aaf756-2064-5f5e-985b-9c4bd4eb0769
DOI
10.1101/163584
Open publication

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Multi-scale immune selection and the transmission-diversity feedback of <i>Plasmodium falciparum</i> malariaDOI 10.1101/163584
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