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Article

Population structure of pathogens: the role of immune selection.

Parasitology today (Personal ed.) - 1 Dec 1999

Gupta S, Anderson R M

Abstract excerpt

Sunetra Gupta and Roy Anderson discuss how the balance between host immune responses against conserved and variable antigens shapes the population structure of pathogens. At one extreme, immune selection against polymorphic determinants can cause pathogen populations to self-organize spontaneously into discrete antigenic types that may either be maintained over long periods or undergo cyclical or chaotic...

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Identifiers

PMID: 10557151
DOI: 10.1016/s0169-4758(99)01559-8

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