Article

p53 as a Convergent Genetic Modifier in Chronic Kidney Disease: Unifying Genetic Risk and Defining Renal Modulatory Drugs

2026-04-19

Abstract excerpt

<title>Abstract</title> <p>Background Chronic kidney disease (CKD) affects more than 850 million individuals worldwide. Secondary genetic risk modifiers including APOL1, MYH9, GPX1, SOD2, ACE, AGT, AQP11, MBL2, PLA2R1, ABCG8, and MBOAT7 operate through mechanistically distinct pathways yet converge on identical tubulointerstitial fibrosis and end-stage kidney disease (ESKD). No unifying molecular framework expla...

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Literature Corpus work: 298ab57d-e22e-50ab-b2cb-aa1f2edbb2c5
DOI: 10.21203/rs.3.rs-9434477/v1

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