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Article

Mechanism-centered target discovery across glomerulonephritis phenotypes: an integrative multi-omics study.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 29 Jun 2026

Liu Jiachen, Qiu Xiaorui, Zeng Dianjie, Li Yue, Wang Yuxi, Gu Jiashu, Kanwar Yashpal S, Chen Leyi, Wei Chenming, Wang Yinhuai, Wang Wenpeng, Sun Liya

Abstract excerpt

BACKGROUND: Glomerulonephritis (GN) comprises a heterogeneous group of immune-mediated kidney disorders with substantial biological and clinical diversity. Current treatment still relies largely on broad immunosuppression, underscoring the need for mechanism-informed target discovery across GN phenotypes. METHODS: We performed a program-guided integrative multi-omics study by combining cis-expression quantitative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42371060
DOI: 10.1007/s00011-026-02299-2

Genes

CDK4
PPP2R1B
SOD1
TNF
ANXA5
GSR
TNFRSF1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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