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Article

Systematic prioritization of potential therapeutic targets for glomerulonephritis using multi-omics Mendelian randomization.

PLoS computational biology - 1 Apr 2026

Li Guoqiang, Jianhan Fu, Gu Jiashu, Wang Yinhuai, Liu Jiachen, Yang Dong, Zeng Dianjie, Zhao Pengcheng

Abstract excerpt

Glomerulonephritis (GN) is an immune-mediated kidney disorder that causes glomerular injury, progressive renal dysfunction, and end-stage kidney disease. Traditional treatments such as corticosteroids and immunosuppressants are limited by variable efficacy and severe adverse effects, highlighting the need for novel therapeutic targets and personalized strategies. We performed a systematic multi-omics Mendelian...

Topics

Mendelian Randomization Analysis
Genome-Wide Association Study
Humans
Quantitative Trait Loci
Glomerulonephritis
Animals
Mice
Proteomics
Bayes Theorem
Transcriptome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Computational Biology

Mice, Knockout

Genetic Predisposition to Disease

Multiomics

Source

Open in PubMed Open full text

Identifiers

PMID: 41990104
DOI: 10.1371/journal.pcbi.1014174
PMCID: PMC13108903

Genes

HCK
CD302
IL6R
MBL2
PEAR1
TIMP4
AFM
BRSK2
C5
CD55
CDKN1B
CFHR5
EPHB2
FHIT
MGP
MTR
PARP1
PRSS3
RECQL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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