Article

Regulatory effects of beta-2-microglobulin on reactive oxygen species generation in polymorphonuclear cells

2025-11-03

Abstract excerpt

Beta-2-microglobulin (β2m) constitutes the invariant light chain of the major histocompatibility complex class I (MHC I) and is present on all nucleated cells, as well as in biological fluids, platelets and neutrophil granules. Immune cells can increase their production and secretion of β2m in response to cytokines such as IFN-γ, IFN-α, and TNF-α. Elevated β2m levels can be detected in various inflammatory, autoim...

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Literature Corpus work: 296913e7-2c54-5308-ab8e-5911720287b7
DOI: 10.1101/2025.10.31.685808

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