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Article

Cellular reactive oxygen species inhibit MPYS induction of IFNβ.

PloS one - 10 Dec 2010

Jin Lei, Lenz Laurel L, Cambier John C

Abstract excerpt

Many inflammatory diseases, as well as infections, are accompanied by elevation in cellular levels of Reactive Oxygen Species (ROS). Here we report that MPYS, a.k.a. STING, which was recently shown to mediate activation of IFNβ expression during infection, is a ROS sensor. ROS induce intermolecul...

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Identifiers

PMID: 21170271
DOI: 10.1371/journal.pone.0015142
PMCID: PMC3000824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21170271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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