Back to search

Article

Activators of Alpha Synuclein Expression Identified by Reporter Cell Line-based High Throughput Drug Screen

2021-06-09

Abstract excerpt

Multiplications, mutations and dysregulation of the alpha synuclein gene ( SNCA ) are associated with the demise of dopaminergic neurons and are considered to play important roles in the pathogenesis of familial and sporadic forms of Parkinson’s disease. Regulation of SNCA expression might thus be an appropriate target for treatment. We aimed to identify specific modulators of SNCA transcription, generated CRISPR/...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
29668cec-6677-5529-83bc-8d229212148d
DOI
10.21203/rs.3.rs-543583/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Activators of Alpha Synuclein Expression Identified by Reporter Cell Line-based High Throughput Drug ScreenDOI 10.21203/rs.3.rs-543583/v1
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s diseaseSemantic proximity
Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.Semantic proximity
CRISPR/Cas9-mediated gene editing induces neurological recovery in an A53T-SNCA overexpression rat model of Parkinson’s diseaseSemantic proximity
Nuclease-dead S. <i>aureus</i> Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s diseaseSemantic proximity
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo.Semantic proximity
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagySemantic proximity
Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9.Semantic proximity
Deregulation of α-synuclein in Parkinson’s disease: Insight from epigenetic structure and transcriptional regulation of SNCASemantic proximity
Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative DiseaseSemantic proximity
Global Effects of a PD Risk-SNP at the Alpha-Synuclein LocusSemantic proximity
A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expressionSemantic proximity
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.