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Article

Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9.

Neuroscience bulletin - 1 Feb 2017

Lu Shenzhao, Zhou Jiawei

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide, but its cause and pathogenesis are still not fully understood. Earlier studies have shown that SNCA, which encodes α-synuclein, is one of the key genes associated with PD. Single-nucleotide polymorphism (SNP) variants of SNCA are thought to be correlated with disease onset. The underlying mechanisms however are...

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Source

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Identifiers

PMID: 27743341
DOI: 10.1007/s12264-016-0065-2
PMCID: PMC5567539

Genes

SNCA

Provenance

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