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β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

31 Aug 2017

Abstract excerpt

Elucidating the risk of Parkinson's disease High expression of the α-synuclein gene ( SNCA ) is a risk factor for Parkinson's disease (PD), but certain drugs may mitigate this risk. Mittal et al. ran a small-molecule screen to identify compounds that regulate levels of SNCA expression and found that several β2-adrenoreceptor (β2AR) agonists reduced them (see the Perspective by Snyder). These compounds modulated...

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PMID: 28860381
DOI: 10.1126/science.aaf3934

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