Article

Role of CD28 in Acute Graft-Versus-Host Disease

1998-10-15

Abstract excerpt

Abstract Because CD28-mediated T-cell costimulation has a pivotal role in the initiation and maintenance of T-cell responses, we tested the hypothesis that CD28 is critical for the development of graft-versus-host disease (GVHD). We compared the in vivo effects of CD28−/− T cells transplanted from B6 donor with the CD28 gene deleted by homologous recombination with those of CD28+/+ T cells transplanted from wild-t...

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Literature Corpus work: 295ce189-6f3d-5cf8-be7f-0e3d9897058f
DOI: 10.1182/blood.v92.8.2963

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