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Article

Restoration of CD28 Expression in CD28− CD8 <b>+</b> Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production

8 Sept 2003

Abstract excerpt

The control of many persistent viral infections by Ag-specific cytolytic CD8+ T cells requires a concurrent virus-specific CD4+ Th cell response. This reflects in part a requirement of activated effector CD8+ T cells for paracrine IL-2 production as a growth and survival factor. In human CMV and HIV infection, the majority of differentiated virus-specific CD8+ T cells notably lose the ability to produce IL-2 but...

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Identifiers

PMID: 12963692
DOI: 10.1084/jem.20021288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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