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Article

CD28 extinction in human T cells: altered functions and the program of T‐cell senescence

9 May 2005

Abstract excerpt

The loss of CD28 expression on T cells is the most consistent biological indicator of aging in the human immune system, and the frequency of CD28(null) T cells is a key predictor of immune incompetence in the elderly. There is also mounting evidence for the high frequency of these unusual T cells among patients with inflammatory syndromes or with chronic infections disproportionate with their age. In these...

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PMID: 15882352
DOI: 10.1111/j.0105-2896.2005.00256.x

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