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Article

Critical role of CD28 in protective immunity against Salmonella typhimurium.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1999

Mittrücker H W, Köhler A, Mak T W, Kaufmann S H

Abstract excerpt

Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28-/- mice were highly susceptible to...

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Identifiers

PMID: 10586076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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