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Article

Graded function of CD80 and CD86 in initiation of T-cell immune response and cardiac allograft survival.

Transplant international : official journal of the European Society for Organ Transplantation - 1 Feb 2008

Xiang Jianbin, Gu Xiaodong, Qian Shiguang, Chen Zongyou

Abstract excerpt

CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4), which have opposing functions in T-cell responses, share the two ligands, CD80 (B7-1) and CD86 (B7-2). To understand the functions of CD80 and CD86, respectively, CD80(low) dendritic cells (DCs) and CD86(low) DCs were prepared by using RNA interference. Then CD80 and CD86 functions were analysed by in vitro mixed lymphocyte reaction and cytokine production...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17971032
DOI: 10.1111/j.1432-2277.2007.00590.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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