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Article

Engineered uterine primary myometrial cells with high-mobility group AT-hook 2 overexpression display a leiomyoma-like transcriptional and epigenomic phenotype.

F&S science - 1 Nov 2024

Saini Priyanka, Holmes Austin G, Wei Jian-Jun, Parker J Brandon, Chakravarti Debabrata

Abstract excerpt

OBJECTIVE: To determine if engineered high-mobility group AT-hook 2 (HMGA2) overexpressing uterine primary myometrial cells recapitulate the transcriptional and epigenomic features of HMGA2-subtype leiomyomas. DESIGN: Isolated primary, "normal" myometrial cells from three patients were engineered to overexpress HMGA2 to determine how HMGA2 establishes transcriptomic and epigenomic features of HMGA2-overexpressing...

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Share to Epigenomics
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39074663
DOI: 10.1016/j.xfss.2024.07.008
PMCID: PMC11588529

Genes

HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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