Article

“Chronic morphine treatment induces a conserved Smchd1-dependent epigenetic memory that disrupts X-chromosome inactivation and genomic imprinting”

2026-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic memory ensures stable inheritance of gene expression patterns critical for embryonic development. Environmental exposures can disrupt this memory, yet the mechanisms remain unclear. Here we demonstrate that chronic morphine exposure induces a persistent transcriptomic and epigenetic memory by repressing Smchd1 , a key chromatin regulator, in mouse embryonic stem cells, preimplantatio...

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Identifiers and source

Literature Corpus work: 29483410-8515-57ef-be39-49644b8f2266
DOI: 10.64898/2026.03.23.713629

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