Article

<i>Smchd1</i> is a maternal effect gene required for autosomal imprinting

2020-01-21

Abstract excerpt

Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific epigenetic marks. These marks are under the control of maternal effect proteins supplied in the oocyte. Here we report the epigenetic repressor Smchd1 as a novel maternal effect gene that regulates imprinted expression of 16 genes. Most Smchd1-sensitive genes only show loss of imprinti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b07cf261-63a3-5e9c-9e9b-67d62bf735f4
DOI: 10.1101/2020.01.20.913376

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Smchd1</i> is a maternal effect gene required for autosomal imprintingDOI 10.1101/2020.01.20.913376Read

Smchd1 is a maternal effect gene required for genomic imprinting.Semantic proximity Read

A New Role for SMCHD1 in Life's Master Switch and Beyond.Semantic proximity Read

The Epigenetic Regulator SMCHD1 in Development and Disease.Semantic proximity Read

Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.Semantic proximity Read

Many faces of SMCHD1.Semantic proximity Read

A maternal-effect <i>Padi6</i> variant results in abnormal nuclear localization of DNMT1 and failure of epigenetic reprogramming and zygotic genome activation in mouse embryosSemantic proximity Read

SMCHD1 is a novel target for gene-activation therapy to treat Prader-Willi SyndromeSemantic proximity Read

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in diseaseSemantic proximity Read

SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes.Semantic proximity Read

Independent recruitment of PRC1 and PRC2 by human XISTSemantic proximity Read

Conservation and divergence of canonical and non-canonical imprinting in muridsSemantic proximity Read

Relating SMCHD1 structure to its function in epigenetic silencing.Semantic proximity Read