Chronic morphine treatment leads to a global DNA hypomethylation via active and passive demethylation mechanisms in mESCs

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic changes are essential for normal development and ageing, but there is still limited understanding of how environmental factors can cause epigenetic changes that leads to health problems or diseases. Morphine is known to pass through the placental barrier and impact normal embryo development by affecting the neural tube, frontal cortex and spinal cord development, and, as a consequence...

Topics

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• Birth, Development, and Health
• Cancer, Stress, Anesthesia, and Immune Response
• Diet and metabolism studies
• Epigenetics and DNA Methylation
• Pain Management and Opioid Use
• Pharmacological Effects and Toxicity Studies
• Prenatal Substance Exposure Effects
• Testicular diseases and treatments

Identifiers and source

Literature Corpus work

3621cd29-324a-5f20-b6be-80842817bcd1

DOI

10.1101/2025.03.16.643512