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Article

Smchd1 is a maternal effect gene required for genomic imprinting.

eLife - 13 Nov 2020

Wanigasuriya Iromi, Gouil Quentin, Kinkel Sarah A, Tapia Del Fierro Andrés, Beck Tamara, Roper Ellise A, Breslin Kelsey, Stringer Jessica, Hutt Karla, Lee Heather J, Keniry Andrew, Ritchie Matthew E, Blewitt Marnie E

Abstract excerpt

Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific epigenetic marks. These marks are under the control of maternal effect proteins supplied in the oocyte. Here we report epigenetic repressor Smchd1 as a novel maternal effect gene that regulates the imprinted expression of ten genes in mice. We also found zygotic SMCHD1 had a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33186096
DOI: 10.7554/eLife.55529
PMCID: PMC7665889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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