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Article

A New Role for SMCHD1 in Life's Master Switch and Beyond.

Trends in genetics : TIG - 1 Dec 2019

Schall Peter Z, Ruebel Meghan L, Latham Keith E

Abstract excerpt

Structural maintenance of chromosomes flexible hinge-domain containing protein 1 (SMCHD1) has emerged as a key regulator of embryonic genome function. Its functions have now extended well beyond the initial findings of effects on X chromosome inactivation associated with lethality in female embryos homozygous for a null allele. Autosomal dominant effects impact stem cell properties as well as postnatal health....

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Identifiers

PMID: 31668908
DOI: 10.1016/j.tig.2019.10.001
PMCID: PMC6884149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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