Article

PKD1-tau disulfide linkage promotes tau phosphorylation and tau accumulation in a tauopathy mouse model

2025-10-13

Abstract excerpt

<title>Abstract</title> <p>Abnormal accumulation of the microtubule-interacting protein tau is a characteristic feature of numerous neurodegenerative disorders, including Alzheimer’s disease (AD). Oxidative stress, a pivotal factor in neurodegeneration, contributes to aberrant formation of insoluble tau aggregates and neurotoxicity through mechanisms largely unknown. In this study, we demonstrate that the activat...

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Literature Corpus work: b1f01cae-71f4-5b71-bd7c-3fd2e60acd8b
DOI: 10.21203/rs.3.rs-7655539/v1

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