Article

Slc9a6 mutation causes Purkinje cell loss and ataxia in the <i>shaker</i> rat

2022-03-29

Abstract excerpt

<h4>Background</h4> The shaker rat carries a naturally occurring mutation leading to progressive ataxia characterized by Purkinje cell (PC) loss. We previously reported on fine-mapping the shaker locus to the long arm of the rat X chromosome. In this work, we sought to identify the mutated gene underlying the shaker phenotype and confirm its identity by functional complementation. <h4>Methods</h4> We fine-map...

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Literature Corpus work: 0a137056-b31d-5c2f-a89b-3c59fd7271fd
DOI: 10.1101/2022.03.28.486143

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