Article

Dark kinase annotation, mining and visualization using the Protein Kinase Ontology

2022-03-01

Abstract excerpt

<h4>ABSTRACT</h4> The Protein Kinase Ontology (ProKinO) is an integrated knowledge graph that conceptualizes the complex relationships connecting protein kinase sequence, structure, function, and disease in a human and machine-readable format. Here we extend the scope of ProKinO as a discovery tool by including new classes and relationships capturing information on kinase ligand binding sites, expression patterns...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 272a74b3-a487-5dbf-b7f9-2063bf71f292
DOI: 10.1101/2022.02.25.482021

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dark kinase annotation, mining and visualization using the Protein Kinase OntologyDOI 10.1101/2022.02.25.482021Read

ProKinO: A Unified Resource for Mining the Cancer KinomeSemantic proximity Read

Kinase Interaction Network Expands Functional and Disease Roles of Human KinasesSemantic proximity Read

KinView: a visual comparative sequence analysis tool for integrated kinome research.Semantic proximity Read

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinasesSemantic proximity Read

Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers.Semantic proximity Read

Kin-Driver: a database of driver mutations in protein kinases.Semantic proximity Read

Deep Learning enabled discovery of kinase drug targets in PharosSemantic proximity Read

A patient-centric knowledge graph approach to prioritize mutants for selective anti-cancer targetingSemantic proximity Read

The Clinical Kinase Index: Prioritizing Understudied Kinases as Targets for the Treatment of CancerSemantic proximity Read

KinaseMD: kinase mutations and drug response database.Semantic proximity Read

A resource for exploring the understudied human kinome for research and therapeutic opportunitiesSemantic proximity Read

Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.Semantic proximity Read