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A cross-species approach using an <i>in vivo</i> evaluation platform in mice demonstrates that sequence variation in the human <i>RABEP2</i> gene modulates ischemic stroke outcomes

2022-07-01

Abstract excerpt

Ischemic stroke, caused by vessel blockage, results in cerebral infarction; the death of brain tissue. Previously, quantitative trait locus mapping (QTL) of cerebral infarct volume and collateral vessel number identified a single, strong genetic locus regulating both phenotypes. Additional studies identified the causative gene, encoding RAB GTPase Binding Effector Protein 2 ( Rabep2 ). However, there is yet no ev...

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Literature Corpus work
2933d177-11c2-5544-bbe8-cc2f36da535a
DOI
10.1101/2022.06.29.498109
Open publication

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A cross-species approach using an <i>in vivo</i> evaluation platform in mice demonstrates that sequence variation in the human <i>RABEP2</i> gene modulates ischemic stroke outcomesDOI 10.1101/2022.06.29.498109
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