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Article

A mouse model of heritable cerebrovascular disease.

PloS one - 31 Dec 2010

Sproule Thomas J, Sled John G, Wentzell Jill, Wang Bing, Henkelman R Mark, Roopenian Derry C, Burgess Robert W

Abstract excerpt

The study of animal models of heritable cerebrovascular diseases can improve our understanding of disease mechanisms, identify candidate genes for related human disorders, and provide experimental models for preclinical trials. Here we describe a spontaneous mouse mutation that results in reproducible, adult-onset, progressive, focal ischemia in the brain. The pathology is not the result of hemorrhage, embolism,...

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Share to Cerebrovascular Disorders
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21217823
DOI: 10.1371/journal.pone.0015327
PMCID: PMC3013100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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