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Article

Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.

PLoS genetics - 1 Jan 2013

Keum Sehoon, Lee Han Kyu, Chu Pei-Lun, Kan Matthew J, Huang Min-Nung, Gallione Carol J, Gunn Michael D, Lo Donald C, Marchuk Douglas A

Abstract excerpt

During ischemic stroke, occlusion of the cerebrovasculature causes neuronal cell death (infarction), but naturally occurring genetic factors modulating infarction have been difficult to identify in human populations. In a surgically induced mouse model of ischemic stroke, we have previously mapped Civq1 to distal chromosome 7 as a quantitative trait locus determining infarct volume. In this study, genome-wide...

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Identifiers

PMID: 24130503
DOI: 10.1371/journal.pgen.1003807
PMCID: PMC3794904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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