Article
Effects of a Global Rab27a Null Mutation on Murine PVAT and Cardiovascular Function.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2024
Soucy Ashley, Potts Christian, Kaija Abigail, Harrington Anne, McGilvrey Marissa, Sutphin George L, Korstanje Ron, Tero Benjamin, Seeker Jacob, Pinz Ilka, Vary Calvin, Ryzhova Larisa, Liaw Lucy
Abstract excerpt
BACKGROUND: RAB27A is a member of the RAS oncogene superfamily of GTPases and regulates cell secretory function. It, is expressed within blood vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function. METHODS: Body weight of Rab27aash mice was measured from 2 to 18 months of age, along with glucose resorption at 6 and 12 months of age and glucose sensitivity...
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