Article
BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.
Circulation - 18 Jul 2017
McClung Joseph M, McCord Timothy J, Ryan Terence E, Schmidt Cameron A, Green Tom D, Southerland Kevin W, Reinardy Jessica L, Mueller Sarah B, Venkatraman Talaignair N, Lascola Christopher D, Keum Sehoon, Marchuk Douglas A, Spangenburg Espen E, Dokun Ayotunde, Annex Brian H, Kontos Christopher D
Abstract excerpt
BACKGROUND: Critical limb ischemia is a manifestation of peripheral artery disease that carries significant mortality and morbidity risk in humans, although its genetic determinants remain largely unknown. We previously discovered 2 overlapping quantitative trait loci in mice, Lsq-1 and Civq-1, that affected limb muscle survival and stroke volume after femoral artery or middle cerebral artery ligation,...
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