Association study of <i>DNAJC13, UCHL1, HTRA2, GIGYF2</i> and <i>EIF4G1</i> with Parkinson’s disease

Abstract excerpt

Rare mutations in genes originally discovered in multi-generational families have been associated with increased risk of Parkinson’s Disease (PD). The involvement of rare variants in DNAJC13, UCHL1, HTRA2, GIGYF2 and EIF4G1 loci have been poorly studied or produced conflicting results across cohorts. However, they are still being often referred to as “PD-genes” and used in different models. To further elucidate th...

Topics

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• Exome Sequencing
• Genetic Predisposition to Disease
• HSP40 Heat-Shock Proteins
• Mendelian Randomization Analysis
• Molecular Chaperones
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

2932c27f-af1a-51ba-b854-66799cd38cd7

DOI

10.1101/2020.06.26.20141176